Research Roundup

Debbie Rigby presents the latest research relevant to pharmacists from around the world

An In-Depth Analysis of Patient-Reported Outcomes in Patients With Chronic Hepatitis C Treated With Different Anti-Viral Regimens

Patient-reported outcomes on the use of all-oral direct acting antivirals for the treatment of chronic hepatitis C show better patient experience and work productivity during treatment. Data from multicenter multinational phase 3 clinical trials of sofosbuvir with and without interferon or ribavirin showed a sustained virological response 12 weeks post-treatment (SVR12) regardless of regimen.

The American Journal of Gastroenterology, 29 March 2016.


Proton Pump Inhibitors and Risk of Incident CKD and Progression to ESRD

This review of 173,321 patients on PPIs and 20,270 on H2 antagonists, with follow-up over 5 years, found that PPIs had a significantly elevated risk of doubling of serum creatinine level, an increased risk of incident eGFR decline > 30% and end stage renal disease compared to H2-blockers.

Journal of the American Society of Nephrology. Published online April 14, 2016.
Medscape summary


Dietary Interventions in Irritable Bowel Syndrome

This article provides a rationale as to why specific diets might improve IBS symptoms. Elimination of one food (ie, lactose, fructose, excess fiber, fructans, and galactans) at a time may improve GI symptoms. A low FODMAP diet may help patients who have failed individual dietary interventions.

Clin Gastroenterol Hepatol. 2015;13(11):1899-1906. 


Efficacy and Safety of Canagliflozin in Individuals Aged 75 and Older With Type 2 Diabetes Mellitus

Canagliflozin, a SGLT2 inhibitor for the treatment of type 2 diabetes, improves glycaemic control, body weight, and BP in people aged 75 and older. Randomized Phase 3 studies have shown the overall incidence of adverse events is high across treatment groups in participants aged 75 and older and higher than in those younger than 75.

J Am Geriatr Soc. 2016;64(3):543-552. 


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