Research Roundup

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 Debbie Rigby takes a look at the latest in research news

Dipeptidyl peptidase-4 inhibitors and incidence of inflammatory bowel disease among patients with type 2 diabetes

A large UK-based cohort study has shown the use of dipeptidyl peptidase-4 inhibitors is associated with an increased risk of inflammatory bowel disease in patients with type 2 diabetes. Hazard ratios gradually increased with longer durations of use, reaching a peak after three to four years of use decreasing after more than four years of use.

BMJ 2018;360:k872.


What low back pain is and why we need to pay attention

Low back pain is an extremely common symptom characterised by a range of biophysical, psychological, and social dimensions that impair function. It is commonly accompanied by pain in one or both legs and some people with low back pain have associated neurological symptoms in the lower limbs. This article explores the risk factors and triggers for episodes of low back pain and the global burden of the condition.

Lancet, Published online March 21, 2018




Prevention and treatment of low back pain: evidence, challenges, and promising directions

Guidelines on treatment of low back pain recommend self-management, physical and psychological therapies, and some forms of complementary medicine, and place less emphasis on pharmacological and surgical treatments; routine use of imaging and investigations is not recommended.

Lancet, Published online March 21, 2018


Neuropathic pain

Neuropathic pain is pain caused by a lesion or disease of the somatosensory nervous system, and generally occurs as chronic pain that escalates. General manifestations of neuropathy include allodynia, anesthesia dolorosa, hyperalgesia, and hyperpathia. The management of neuropathic pain is typically a multimodal process, with first-line treatments including TCAs, SNRIs, gabapentin or pregabalin.

Pharmacy Times 2018.

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