Research roundup

Debbie Rigby presents the latest research new relevant to pharmacy

It is time to stop prescribing oral salbutamol

There is minimal evidence to support the use of oral salbutamol for the management of asthma. There is no evidence for any benefit in bronchiolitis or acute cough. Oral salbutamol preparations lead to a slower bronchodilator response than inhaled salbutamol. Current guidelines recommend the use of salbutamol by metered-dose inhaler via a spacer in the treatment of mild, moderate and severe acute asthma.

Aust Fam Physician 2016;45(4):245-7.


Intensive vs Standard Blood Pressure Control and Cardiovascular Disease Outcomes in Adults Aged ≥75 Years

Among ambulatory adults aged 75 years or older, treating to an SBP target of less than 120 mm Hg compared with an SBP target of less than 140 mm Hg resulted in significantly lower rates of fatal and nonfatal major cardiovascular events and death from any cause.

JAMA. Published online May 19, 2016.


Ventricular tachyarrhythmia and sudden cardiac death with domperidone use in Parkinson’s disease

Domperidone is preferentially used over other antiemetic agents to treat digestive symptoms in Parkinson’s disease. A multicentre retrospective cohort study using administrative databases has shown that domperidone use may increase the risk of VT/SCD in patients with PD, particularly those with a history of cardiovascular disease. Dose and duration of use did not affect the magnitude of the risk.

British Journal of Clinical Pharmacology 2016


Antidepressants and the risk of hyponatremia

A retrospective register-based cohort study using Danish nationwide registers has shown all ll antidepressants except mianserin are associated with hyponatremia. Incidence rate ratios were highest for citalopram, followed by clomipramine, mirtazapine, venlafaxine, duloxetine and mianserin.

BMJ Open 2016;6:e011200



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