Research Roundup

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Debbie Rigby rounds up the latest in research news

Patient-centered care interventions to reduce the inappropriate prescription and use of benzodiazepines and z-drugs

A systematic review of 20 studies has identified interventions to promote patient-centred treatments for inappropriate benzodiazepine and Z-drug use. Patient-centered interventions that provided patient information (e.g. self-help booklet) effectively increased the appropriate use of benzodiazepines. The combination of physician contact and written information was superior to only written information. A comprehensive educational outreach program (“academic detailing”) for HCPs and medication reviews by pharmacists were also effective.   

PeerJ 6:e5535.


Pharmacological properties of cannabidiol in the treatment of psychiatric disorders

A critical overview of cannabidiol in the treatment of psychiatric disorders shows some effect in schizophrenia, social anxiety disorder and reduction in withdrawal symptoms and cannabis/tobacco dependence. The authors concluded that CBD can reduce psychotic, anxiety and withdrawal symptoms. The usual limitations of cannabis trials were highlighted – small sample size, and inconsistent dosage, formulation and timing of administration.

Epidemiology and Psychiatric Sciences 2018;27(4):327-35.


Pharmacists and medication adherence in asthma

Non-adherence to medicines remains a persistent barrier within asthma care. This systematic review and meta-analysis evaluated how effective pharmacist-led interventions are in improving medication adherence in adults with asthma. Community pharmacy interventions such as the New Medicine Service can significantly increase adherence. The findings suggest that pharmacist-led interventions may be more effective if they are conducted by embedded pharmacists integrated into general practice.

European Respiratory Journal 2018;52:1800485


Adherence to inhaled therapy and its impact on COPD

A retrospective analysis of patients hospitalized for acute exacerbation of COPD demonstrates poor adherence to therapy with only 33.6% showing complete adherence. Patients with complete adherence to therapy had a significantly lower FEV1 compared to those with low adherence. The risk of exacerbations leading to hospitalization was 10-fold higher in patients with severe COPD. Factors associated with better adherence were age, former smoking, and more severe airflow limitation.

BMC Pulmonary Medicine2018;18:163.

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