Research Roundup

Debbie Rigby rounds up the latest in research news

Paracetamol versus placebo for knee and hip osteoarthritis

Based on high‐quality evidence this Cochrane review confirms that paracetamol provides only minimal improvements in pain and function for people with hip or knee osteoarthritis, with no increased risk of adverse events overall. Subgroup analysis indicates that the effects on pain and function do not differ according to the dose of paracetamol.

Cochrane Database of Systematic Reviews 2019, Issue 2.


Drug-related problems in patients with rheumatoid arthritis

This retrospective study conducted in Malaysia identified drug-related problems associated with rheumatoid arthritis. The most common DRPs encountered were adverse reactions (38.8%), drug interactions (33.6%), and drug-choice problems (14.5%). Factors that had significant association with the occurrence of DRPs were polypharmacy, multiple comorbidities, hyperlipidemia, osteoarthritis, and renal impairment.

Therapeutics and Clinical Risk Management 2019;15:505-24.


Medication adherence interventions and outcomes

An overview of 8 systematic reviews and 37 RCTs has concluded that patient education and counselling showed some positive effects on medication adherence. No single strategy showed improvement in all settings. Interventions delivered by pharmacists and nurses showed a better result in improving adherence and outcomes than interventions delivered by general practitioners.

Eur J Hosp Pharm 2018;0:1–6.


Pharmacists’ views on the upscheduling of codeine-containing analgesics to ‘prescription only’ medicines in Australia

An anonymous self-administered online questionnaire between March and May 2018 after the upscheduling of codeine-containing analgesics has shown mixed views from pharmacists. both Advantages and disadvantages were perceived by 113 pharmacists. The authors concluded improving education and up-skilling in this space is essential.

International Journal of Clinical Pharmacy 2019:1-8.


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