Research Roundup

Debbie Rigby rounds up the latest in research news

The effects of single inhaler triple therapy vs single inhaler dual therapy or separate triple therapy for the management of chronic obstructive pulmonary disease

A systematic review and meta-analysis of 7 randomized controlled trials has shown Single inhaler triple therapy is associated with a significantly lower risk of COPD exacerbation compared with LABA/LAMA and ICS/LABA dual therapy. Single inhaler triple therapy led to a more significant improvement in lung function and quality of life compared with LABA/LAMA and ICS/LABA dual therapy. Single inhaler triple therapy was associated with a higher risk of pneumonia compared with LABA/LAMA dual therapy.

International Journal of Chronic Obstructive Pulmonary Disease 2019;14:1539–1548.


Management of multimorbidity using a patient-centred care model

A pragmatic cluster-randomised trial in general practices in England and Scotland explored the impact of a patient-centred approach based on dimensions of health, depression, and drugs for patients with multimorbidity (three or more long term conditions, mean age 71 years). After 15 months follow-up, there was no improvement in patients’ quality of life.

Lancet 2018;392:41–50.i

Post hoc study


Reduction in Use of Risperidone for Dementia in Australia Following Changed Guidelines

Data from DVA and PBS shows TGA labelling changes in June 2015 have contributed to a significant reduction in the rate of use of risperidone for behavioural and psychological symptoms of dementia in veterans living in both the aged care and community settings, and in the general older Australian population. The labelling changes were also associated with a reduced duration of risperidone use in aged care residents, although for most people the duration of use still exceeded the recommended 12-week maximum duration.

Pharmacy 2019:7(3):100.


Effects of non‐dispensing pharmacists integrated in general practice on medication‐related hospitalisations

In a multicentre, nonrandomised, controlled intervention study with pre–post comparison in 25 general practices in the Netherlands, general practices with an integrated non‐dispensing pharmacist, the rate of medication‐related hospitalisations was lower compared to usual care. Non‐dispensing pharmacists provided a broad range of medication therapy management services both on patient level (e.g. clinical medication review) and practice level (e.g. quality improvement projects).

British Journal of Clinical Pharmacology, first published 25 June 2019.

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