Research Roundup

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Debbie Rigby rounds up the latest in research news

Benefits and Harms of Oral Anticoagulant Therapy in Chronic Kidney Disease

A systematic review and meta-analysis has shown non–vitamin K oral anticoagulants had a benefit–risk profile superior to that of VKAs (warfarin) in people with early-stage chronic kidney disease; however, there was insufficient evidence to establish benefits or harms of VKAs or NOACs for advanced CKD or dialysis-dependent end-stage kidney disease. In all trials combined, NOACs seemingly reduced major bleeding risk compared with VKAs.

Ann Intern Med. 2019.


Consumption of Fish and Long-chain n-3 Polyunsaturated Fatty Acids Is Associated With Reduced Risk of Colorectal Cancer

In an analysis of dietary patterns of participants in the EPIC study, regular consumption of fish, at recommended levels, was found to be associated with a lower risk of colorectal cancer, possibly through exposure to long-chain n-3 polyunsaturated fatty acids.

Clinical Gastroenterology and Hepatology, available online 25 June 2019.


Sulfonylureas as initial treatment for type 2 diabetes and the risk of adverse cardiovascular events

Sulfonylureas are recommended as second‐line treatment in the management of type 2 diabetes. However, they are still commonly used also as first‐line treatment instead of metformin. In this population‐based cohort study of patients with newly treated type 2 diabetes, sulfonylureas were associated with higher rates of ischaemic stroke, cardiovascular death, and all‐cause mortality. An additional 2.0 ischaemic strokes, 3.5 cardiovascular deaths, and 21.4 all‐cause deaths per 1,000 patients per year were associated with sulfonylureas as first-line therapy.

British Journal of Clinical Pharmacology, first published 5 July 2019.


Counseling interactions between patients living with persistent pain and pharmacists in Australia: are we on the same page?

Results of a survey of Australian patients and pharmacists show a disparity in the nature of the interaction and information that patients wanted from pharmacists, compared to what was provided by pharmacists. Whilst the majority of patients thought pharmacists provided good information about medications, half of the patients wanted a caring, empathetic, respectful, and private conversation with the pharmacist. The authors suggested further training and education for pharmacists to better engage in patient-centered care when interacting with people living with persistent pain, thereby improving health outcomes for these patients.

Journal of Pain Research 2019;12:2441–2455.

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