Research Roundup

Debbie Rigby rounds up the latest in research news

Association between headache and low back pain

A systematic review of 14 studies identified a positive association between persistent low back pain and primary headache disorders in different populations. The odds ratio of the relationship between primary headache and low back pain ranged from 1.55 to 8.00.

The Journal of Headacche and Pain 2019;20:82.


Homeopathy for treatment of irritable bowel syndrome

A Cochrane review of 4 RCTs (307 participants) has concluded evidence is lacking regarding the effectiveness and safety of homeopathy for the treatment of IBS. None of the included studies reported on abdominal pain, stool frequency, stool consistency, or adverse events.

Cochrane Database of Systematic Reviews 2019, Issue 9.


Codeine use and harms in Australia: evaluating the effects of re‐scheduling

Analysis of monthly opioid exposure calls to New South Wales Poisons Information Centre shows a significant reduction in codeine poisoning after upscheduling of codeine from February 2018. During the same period low-strength codeine sales decreased by 87.3% with no increase in high-strength codeine sales in the 14 months following re-scheduling. The authors concluded codeine re‐scheduling in Australia appears to have reduced codeine misuse and sales.

Addiction, first published 2 October 2019.



Pharmacovigilance assessment of the association between Fournier’s gangrene and other severe genital adverse events with SGLT-2 inhibitors

Case reports detailed in this publication show SGLT2i may predispose to Fournier’s gangrene and other severe genital adverse events. Fournier’s gangrene is a severe form of perineal necrotising fasciitis, which can lead to sepsis and death if not promptly treated with antibiotics and surgery.


BMJ Open Diab Res Care 2019;7:e000725.

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