Research Roundup

Debbie Rigby rounds up the latest in research news

Amiodarone in the aged

Amiodarone is a highly effective antiarrhythmic drug, but can have serious adverse effects, particularly in older patients. Potential drug interactions when other drugs are prescribed with amiodarone should be considered. Amiodarone should be avoided in patients with significant conduction system disease, significant liver or pulmonary disease, or hyperthyroidism. Safer alternative drugs should be used preferentially in older patients with atrial fibrillation.

Aust Prescr 2019;42:158–62.


Bedtime hypertension treatment improves cardiovascular risk reduction

A large prospective trial bedtime dosing of antihypertensives results in improved ambulatory blood pressure control (significantly enhanced decrease in asleep BP and increased sleep-time relative BP decline, i.e. BP dipping) and, most importantly, markedly diminished occurrence of major CVD events (HR 0.55), including CVD death, myocardial infarction, coronary revasculisation, heart failure and stroke.

European Heart Journal, 2019.


Experience of living with knee osteoarthritis

This systematic review of 26 articles highlights the value of considering patient attitudes and experiences including psychosocial factors when planning and implementing management options for people with knee osteoarthritis. In particular, to improve their psychosocial well-being, by reducing pain, maintaining function, increasing social and physical activity participation, helping patients to remain in employment and achieve optimal mental health.

BMJ Open 2019;9:e030060.


Altered microbiome composition in individuals with fibromyalgia

Fibromyalgia is a prevalent syndrome, characterised by chronic widespread pain, fatigue, and impaired sleep, that is challenging to diagnose and difficult to treat. Results of this study provide evidence for alterations of gut microbiome in fibromyalgia.

Pain 2019;160(11):2589-2602.

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