Research Roundup

Debbie Rigby rounds up the latest in research news

Association of tramadol use with risk of hip fracture

Tramadol was associated with a higher risk of hip fracture than initiation of codeine and commonly used NSAIDs in an analysis of a UK database. Compared to codeine, tramadol was associated with a 28% increased risk of hip fracture. Naproxen, ibuprofen, celecoxib and etoricoxib had a higher risk of hip fracture than the tramadol cohort.

Journal of Bone and Mineral Research, first published 5 February 2020.


Aspirin and fracture risk

A systematic review and exploratory meta-analysis of 12 observational studies shows a 17% lower odds for any fracture in aspirin users comapred to non-users. Aspirin was associated with a higher hip and lumbar spine bone mineral density (BMD) in women and men. The authors noted that While the reduction in fracture risk was small, given the widespread use of aspirin and the high prevalence of undetected low bone density, even small reductions in fracture risk may yield considerable benefits at a population level.

BMJ Open 2020;10:e026876.


Effect of High-Dose vs Standard-Dose Vitamin D Supplementation in Pregnancy on Bone Mineralization in Offspring Until Age 6 Years

This trial suggests that an increased vitamin D intake during pregnancy has the potential to promote greater bone health in the offspring, which could have a protective effect on risk of fractures. In this double-blinded randomised controlled trial, high dose (28000Iu/day) vitamin D was compared to a stndard daily dose of 400IU taken from pregnancy week 24 until 1 week after birth. Follow-up of length/height, weight, BMI and bone mineral density was followed until age 6 years.

JAMA Pediatr. Published online February 24, 2020.

Medscape summary


Evaluation of a Common Prescribing Cascade of Calcium Channel Blockers and Diuretics in Older Adults With Hypertension

Many older adults with hypertension who are newly dispensed a CCB subsequently receive a loop diuretic. In this population-based cohort study of 41,086 older adults with hypertension, being newly dispensed a calcium channel blocker was associated with a statistically significantly higher rate of being subsequently dispensed a loop diuretic within 90 days compared with 2 groups (n = 66 494 and n = 231 439) who began taking other medications.

JAMA Intern Med. Published online February 24, 2020.

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