Research Roundup

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Debbie Rigby rounds up the latest in research news

Reasons for Nonadherence to Statins

A Systematic Review of Reviews concludes that female gender, older and younger age, non-white race, low socio-economic position, high co-payments, being a new statin user, comorbidities, side effects, regimen complexity, type and intensity of statin dose, smoking, alcohol consumption, imperceptible benefits, and medical distrust contribute to non-adherence.

Patient Preference and Adherence 2020:14 675–691.


Changes in sales of analgesics to pharmacies after codeine was rescheduled as a prescription only medicine

An interrupted time series analysis of sales to pharmacies has demonstrated that rescheduling of codeine was followed by increased sales to pharmacies of paracetamol, ibuprofen, and paracetamol combination products. In contrast, sales of prescription analgesics not containing codeine did not rise. In the 14 months after rescheduling, a small level increase in monthly prescription codeine sales was evident.

Med J Aust 2020:1-7.



Sore throat caused by pharyngitis is commonly seen in primary care. Pharyngitis can be caused by viral, bacterial, or fungal infections. Viral causes are often self-limiting, while bacterial and fungal infections typically require antimicrobial therapy. Pharyngitis caused by Streptococcus pyogenes is among the most concerning owing to its associated severe complications such as acute rheumatic fever and glomerulonephritis.

Canadian Family Physician 2020;66(4):251-257.


Antidepressants for irritable bowel syndrome

Both tricyclic antidepressants (TCAs) and selective serotonin reuptake inhibitors (SSRIs) might improve overall IBS symptoms. About 55% of patients treated with TCAs or SSRIs will benefit compared with about 35% with placebo. Only TCAs improved abdominal pain for about 60% of patients compared with about 30% with placebo. Evidence for antidepressants appears stronger than for antispasmodics, fibre, low FODMAP diet, or probiotics.

Canadian Family Physician 2020;66(4):265.

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