Research Roundup

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Debbie Rigby rounds up the latest in research news

Warfarin and paracetamol interaction

Paracetamol can increase a patient’s INR in a dose-dependent manner. Concomitant use of paracetamol and warfarin can result in a pharmacodynamic interaction leading to a supratherapeutic INR and consequent bleeding. Higher doses of paracetamol over prolonged periods will place patients at greater risk of life-threatening bleeds.

CMAJ 2020;192(19):E506-E508.


Rheumatoid arthritis and osteoarthritis clinical practice guidelines provide few complementary and alternative medicine therapy recommendations

A systematic review has shown 60% of patients with arthritis have used complementary and alternative medicine (CAM) therapies at least once. Common CAM therapies included acupuncture; diet and nutritional supplements; herbal medicine; manipulative therapies such as chiropractic, osteopathic and manual therapies; massage therapy; hydrotherapy; balneotherapy; thermal therapy; homoeopathy; and meditative movement therapies. Popular herbs for arthritis include devil’s claw, Boswellia serrata, rosehip, and traditional Chinese medicines. The finding suggests a need for further research on evidence-based CAM therapies for RA and OA.

Clinical Rheumatology 2020


Necessity and concerns about lipid‐lowering medical treatments and risk factors for non‐adherence

Low or non‐adherence to lipid‐lowering medications is common. This study explored the association between poor adherence to statins and patient beliefs about medicines. Non‐adherence among patients taking lipid‐lowering drugs was high despite most holding positive beliefs regarding medication necessity. Being illiterate, polypharmacy, comorbidities and concerns about side effects are significantly associated with non‐adherence.

International Journal of Clinical Practice, first published 11 April 2020.


Are Opioids Needed to Treat Chronic Low Back Pain?

This review critiques non-pharmacologic and pharmacologic treatment modalities for chronic low back pain and examines the potential of novel opioids and other analgesics that may be a useful addition to the treatment options for patients with chronic pain.

Journal of Pain Research 2020;13:1007-22.

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