Research Roundup

Debbie Rigby rounds up the latest in research news

Effect of Antihypertensive Medication Reduction vs Usual Care on Short-term Blood Pressure Control in Patients With Hypertension Aged 80 Years and Older

Among 569 patients with hypertension aged 80 years and older in a randomised clinical trial, antihypertensive medication reduction was achieved without substantial change in blood pressure control.  

JAMA. 2020;323(20):2039-2051.


Penicillin – getting prescribing right for children

Penicillins are commonly prescribed to children. Recommendations in the product information may not be the most appropriate doses for children and may list clinical indications that are preferably treated with other antibiotics. Reputable guidelines, for example Therapeutic Guidelines: Antibiotic, offer up-to-date advice on optimal choice, route, dosage and duration of oral penicillins in children.

Aust Prescr 2020;43:81–4.


Simplifying Medication Regimens for People Receiving Community-Based Home Care Services

A one-off clinical pharmacist intervention comprising medication reconciliation, assessment of capacity to self-manage medications, and application of a structured 5-step tool has been shown to simplify complex medication regimens. Simplification was possible for 14 participants (56%) and implemented for 7 (50%) at follow-up.

Clinical Interventions in Aging 2020:15 797–809.


Measuring the impact of system level strategies on psychotropic medicine use in aged care facilities

Psychotropic medicine use in aged care facilities remains problematic. A scoping review of 36 studies has shown that system level strategies have the greatest impact on inappropriate use of psychotropic medicines in aged care facilities. Guidelines can influence psychotropic drug use provided the strategies are adopted by aged care facilities.

Research in Social and Administrative Pharmacy 2020;16(6):746-759.

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