Research Roundup

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Debbie Rigby rounds up the latest in research news

Risk of major bleeding among users of direct oral anticoagulants combined with interacting drugs

A population‐based nested case–control study has shown that concurrent use of antiplatelet drugs or selective serotonin reuptake inhibitors with direct-acting oral anticoagulants is associated with nearly 2-fold increased risk of major bleeding leading to hospitalisation. In clinical practice, drugs that increase plasma levels of the DOACs by inhibition of CYP3A4 and/or P‐glycoprotein do not increase the risk of major bleeding.

Br J Clin Pharmacol. 2020;86:1150–1164.


The pharmacological management of vertigo in Meniere disease

This review summarises the pharmacological treatment for vertigo in Meniere disease. Evidence supporting the efficacy for betahistine, diuretics, and intratympanic administration of corticosteroids or gentamicin is limited. Treatment should include therapeutic counselling, sodium-free diet, high-water intake, and a diary of vertigo attacks with symptoms during the episodes.

Expert Opinion on Pharmacotherapy, published online 15 June 2020.


Meta-analysis of proton pump inhibitors induced risk of community-acquired pneumonia

In this meta-analysis of observational studies an increased risk of community-acquired pneumonia (CAP) was identified with low-dose and high-dose PPI use. Use of PPIs for 3-6 months was associated with a twofold risk of developing CAP. There was a statistically significant association between the PPI users and the rate of hospitalization (OR 2.59).

International Journal for Quality in Health Care 2020;32(5):292-9.


Deintensification of Diabetes Medications among Veterans at the End of Life

In this USA retrospective cohort study of nearly 7000 Veterans with diabetes more than 40% were potentially overtreated. Treatment deintensification (discontinuation or dose reduction for a consecutive 7‐day period) occurred in less than one‐half of potentially overtreated Veterans and was strongly associated with low HbA1c values and use of medications with high risk for hypoglycaemia (e.g. sulfonylurea).

Journal of the American Geriatrics Society 2020;68(4):736-45.


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