Research Roundup

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Debbie Rigby takes a look at the latest in research news

Safety of pharmacologic interventions for neuropsychiatric symptoms in dementia

A systematic review and network meta-analysis of 209 studies explored pharmacologic interventions used to treat neuropsychiatric symptoms in dementia. There was a 2-fold increased risk of cerebrovascular events associated with antipsychotics (NNH=99) compared to placebo in persons with dementia. Antipsychotics were associated with increased odds of fracture compared to anticonvulsants (NNH-18) and increased odds of death compared to antidepressants (NNH=47).

BMC Geriatr 20, 212 (2020).

Medication Adherence Report Scale: A measurement tool for eliciting patients’ reports of nonadherence

This study aimed to establish the psychometric properties of a questionnaire measure of patients’ adherence to medications to elicit patients’ report of antihypertensive medication use. The five‐item Medication Adherence Report Scale (MARS‐5) was an effective tool for assessing adherence, identifying patients reporting low adherence and the specific types of nonadherence behaviours (eg, forgetting, deliberately missing doses).

British Journal of Clinical Pharmacology 2020;86(7):1281-8.

Cardiovascular outcomes of type 2 diabetic patients treated with SGLT-2 inhibitors versus GLP-1 receptor agonists in real-life

A retrospective real-world study with over 8,500 people with diabetes from North-East Italy suggests that SGLT2i may be more effective than GLP-1RA in improving cardiovascular outcomes of T2D. Patients with T2D treated with SGLT2i versus GLP-1RA, experienced a lower rate of 3P-MACE (all-cause death, myocardial infarction, stroke), myocardial infarction, hospitalisation for heart failure and hospitalisation for cardiovascular causes.

BMJ Open Diab Res Care 2020;8:e001451.

Rates of PRN Medication Administration in Australian Residential Aged Care

A 12-month audit of prescribing of prn and nurse-initiated medicines in 10 aged care facilities in Victoria highlights the high frequency of PRN analgesic, laxative, and psychotropic medication administration. Three-quarters of residents prescribed a PRN opioid or PRN benzodiazepine and two-thirds of residents prescribed a PRN antipsychotic had the medication administered on 1 or more occasions over the follow-up period of 12 months.

Journal of the American Medical Directors Association, published 28 June 2020

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