Research Roundup

Debbie Rigby rounds up the latest in research news 

Association between topical beta-blockers and risks of cardiovascular and respiratory disease in patients with glaucoma

In this retrospective cohort analysis of 12 336 patients in Taiwan newly diagnosed with glaucoma, topical beta-blockers were not associated with increased risks of cardiovascular and respiratory diseases. The results revealed that topical beta-blocker use might slightly increase the risk of acute respiratory failure. There was also an association with a 40% increased risk of stroke.

BMJ Open 2020;10:e034361.


Sodium–Glucose Cotransporter-2 Inhibitors and the Risk for Diabetic Ketoacidosis

In this population-based cohort study from databases from 7 Canadian provinces and the United Kingdom, SGLT-2 inhibitors were associated with an almost 3-fold increased risk for DKA compared to DPP-4 inhibitors. Age and gender did not modify the association; and prior use of insulin appeared to decrease the risk. The increased risk was across dapagliflozin, empagliflozin and canagliflozin, suggesting a class effect.

Annals of Internal Medicine 2020.


Delayed Denosumab Injections and Fracture Risk Among Patients With Osteoporosis

Denosumab is effective for osteoporosis, but discontinuation leads to rapid reversal of its therapeutic effect. A short delay by 4 to 16 weeks increases the risk of vertebral fractures (HR 1.48); whilst a long delay by more than 16 weeks increases the risk 4-fold. Delay of denosumab dose did not result in statistically significant increased risk of all fracture types.

Annals of Internal Medicine 2020.

Medscape summary


Medication adherence among patients with chronic obstructive pulmonary disease

In this cohort study of patients with COPD, pharmacists were identified as key positive factors in patients’ decisions to adhere to their prescribed COPD treatment regimens. Key roles for pharmacists included advice and counseling related to patients’ medications, inhaler techniques, and the importance of adherence. Patients may benefit from the ongoing instruction in effective inhaler techniques that pharmacists provide, as evidence suggests that IT declines over time.

npj Primary Care Respiratory Medicine (2020) 30:31.


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