Research Roundup


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Debbie Rigby rounds up the latest in research news

Adverse outcomes of proton pump inhibitors in patients with chronic kidney disease

Long‐term use of proton pump inhibitors (PPIs) has been associated with adverse kidney events in the general population. In patients with chronic kidney disease, long-term PPI prescription is common, increasing the risk of progression to end‐stage kidney disease and mortality. The risk of acute kidney injury associated with PPIs was nearly 3-fold in this cohort study.

British Journal of Clinical Pharmacology, 23 December 2020

Blood pressure targets in adults with hypertension

An updated Cochrane review has concluded that for the general population of persons with elevated blood pressure, the benefits of trying to achieve a lower blood pressure target rather than a standard target (≤ 140/90 mm Hg) do not outweigh the harms associated with that intervention. The results of this review are primarily applicable to older people with moderate to high cardiovascular risk.

Cochrane Database of Systematic Reviews 2020, Issue 12.

Systemic adverse effects from inhaled corticosteroid use in asthma

A systematic review of 13 studies has shown conflicting evidence on the impact on bone mineral density. Low quality evidence showed an association with increased infection risk. One study which assessed ocular disorders found an increased risk of cataracts.

BMJ Open Resp Res 2020;7:e000756.

Glucocorticoid use is associated with an increased risk of hypertension

Patients with rheumatoid arthritis are frequently treated with glucocorticoids. This retrospective UK cohort study identified that recent use of glucocorticoids was associated with a 17% increased hazard of hypertension. Only doses above 7.5 mg were significantly associated with hypertension. Cumulative dose did not indicate a clear pattern. The authors recommended regular blood pressure monitoring and treatment where necessary.

Rheumatology 2021;60(1):132–139.

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