Research Roundup

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Debbie Rigby rounds up the latest in research news

Systematic Review of Errors in Inhaler Use: Has Patient Technique Improved Over Time?

A systematic search for articles reporting direct observation of inhaler technique has concluded that incorrect inhaler technique is unacceptably frequent and has not improved over the past 40 years. The most frequent MDI errors were in coordination, speed and/or depth of inspiration, and no post-inhalation breath-hold; whilst incorrect preparation, no full expiration before inhalation, and no post-inhalation breath-hold were the most frequent DPI errors.

Chest. 2016;150(2):394-406.


The medication reconciliation process and classification of discrepancies

Medication reconciliation is a part of the medication management process and facilitates improved patient safety during care transitions. This systematic review evaluated the prevalence, types, causes and contributory factors of medication discrepancy. The Australian authors recommended development of a well-designed taxonomy for medication discrepancies and standardized process for conducting and evaluating the practice of medication reconciliation.

Br J Clin Pharmacol 2016;82:645-58.


The feasibility and effect of deprescribing in older adults on mortality and health

A systematic review and meta-analysis conducted by Amy Page et al suggests that deprescribing needs to be considered for older people as a routine component of the ongoing medication review process. The authors conclude that patient-specific deprescribing interventions to reduce polypharmacy may improve longevity.

Br J Clin Pharmacol 2016;82:583-623.


Use of antipsychotics and risk of myocardial infarction

The findings of this meta-analysis support an increased risk of MI in antipsychotic drug users. The he odds for developing MI were 88% higher in patients taking antipsychotics compared with individuals who had not taken antipsychotics.

Br J Clin Pharmacol 2016;82:624-32.



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