Research Roundup

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Debbie Rigby rounds up the latest in research news

Medication review interventions to reduce hospital readmissions in older people

A network meta‐analysis on 25 studies shows medication review in combination with medication reconciliation, patient education, professional education and transitional care, was associated with a 18% lower risk of hospital readmissions compared to usual care. An effect of medication review without co‐interventions was not demonstrated.

Journal of the American Geriatrics Society, first published 12 February 2021.


Too many pills, too many sick older Australians: Working together is key

This article discusses how the enhanced RMMR program addresses barriers and support general practitioners to make medication changes for older Australians. These enhancements are intended to provide a complete cycle of care over nine months, with ongoing collaboration within the healthcare team including residents. This will allow a team approach to medication changes and monitoring resident response over time.

AJGP 2021;50(3):171-4.


Prophylactic antibiotics for adults with chronic obstructive pulmonary disease

This Cochrane network meta‐analysis of 8 trials has concluded that prolonged administration of macrolides appeared beneficial in prolonging the time to next exacerbation, improving quality of life, and reducing serious adverse events, compared to placebo. No clear benefits were associated with use of quinolones or tetracyclines. Concerns remain about antibiotic resistance with long-term use of antibiotics.

Cochrane Database of Systematic Reviews 2021, Issue 1.


Fracture risk prediction and the decision to treat low bone density

In patients without a prevalent fracture, guidelines recommend initiating therapy based on a calculation of absolute fracture risk. Two common calculators are used in Australia – FRAX (Australia) and Garvan Fracture Risk Calculator (Garvan). The aim of this article is to examine whether the decision to treat with bone-preserving medication would be different depending on which calculator was used.

AJGP 2021;50(3):165-170.

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