Research Roundup

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Debbie Rigby rounds up the latest in research news

Multiple short courses of corticosteroids in children

Short courses of oral steroids (less than two weeks) in children are very unlikely to cause long-term side effects in children. Dose tapering is not required for courses under two weeks’ duration. One month of 1–2 mg/kg/day prednisolone may be sufficient to cause adrenal suppression lasting for up to one year. High-dose inhaled steroids can also have significant long-term side effects.

AJGP 2021;50(3):151-6.


IASP presidential task force on cannabis and cannabinoid analgesia position statement

Due to the lack of high-quality clinical evidence, the International Association for the Study of Pain (IASP) does not currently endorse general use of cannabis and cannabinoids for pain relief. Improved understanding of the clinical pharmacology of cannabis and cannabinoids in a pain relief setting is needed. Expansion in the range of chemical entities tested, elucidation of dose effects, and the optimisation of drug delivery is required.

Pain March 16, 2021


Dietary magnesium and migraine in adults

Analysis of population data reveals inadequate consumption of magnesium intake is associated with migraine in U.S. adults aged 20–50 years. Magnesium consumption was associated with lower odds of migraine for both dietary (OR 0.76) and total magnesium intake (OR 0.78).

Headache 2021;61(2):276-86.


Drug‐drug Interactions with Warfarin

A Systematic Review and Meta‐analysis has confirmed an increased risk of clinically relevant bleeding with concomitant use of warfarin and antiplatelets, many antimicrobials, NSAIDs including COX-2 inhibitors, SSRIs, mirtazapine, and loop diuretics. A protective effect of proton pump inhibitors (PPIs) was found for warfarin‐related gastrointestinal (GI) bleedings. No significant effect on thromboembolic events or mortality of any drug group used with warfarin was found, including single or dual AP regimens.

 British Journal of Clinical Pharmacology, first published 26 March 2021.

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