Debbie Rigby rounds up the latest in research news
NSAIDs used just before and during menses reduce relative mean menstrual blood loss by about 30%, and about 20% to 50% fewer sanitary products are used than with placebo. Effects on bleeding duration are inconsistent. Naproxen, ibuprofen, diclofenac and mefenamic acid were used in the trials.
Canadian Family Physician 2021;67(8):598.
Accredited pharmacists invest significant time in performing comprehensive HMRs, especially during in-home patient consultations and during HMR report collation and completion. For a typical HMR, most spent: <30 minutes preparation, and 30-60 minutes in the home, and 1-3 hours in HMR report collation and completion. This significant HMR time investment as medicines experts provides insight for program and workforce considerations.
Pharmacy Practice 2021;19(3):2376.
Concomitant treatment with a PPI in NOAC-treated patients with AF is associated with a reduced risk of severe upper GI bleeding. This indicates that PPI cotreatment can be considered, in particular among older patients, patients with a HAS-BLED score ≥3, and/or in patients on concomitant antiplatelet therapy.
In a single-centre RCT including 209 patients with moderate to severe COPD, simvastatin at a dose of 40 mg daily significantly prolonged time to first COPD exacerbation and reduced exacerbation rate. Rate of exacerbations over 12 month period was 41% with simvastatin and 59% with placebo; and the annualised exacerbation rate was reduced by 23%.
European Respiratory Journal 2021;58:2001798.