Research Roundup

old bulbs with a smart bulb in middle

Debbie Rigby rounds up the latest in research news

NSAIDs for heavy menstrual bleeding

NSAIDs used just before and during menses reduce relative mean menstrual blood loss by about 30%, and about 20% to 50% fewer sanitary products are used than with placebo. Effects on bleeding duration are inconsistent. Naproxen, ibuprofen, diclofenac and mefenamic acid were used in the trials.

Canadian Family Physician 2021;67(8):598.

Home medicines reviews: a national survey of Australian accredited pharmacists’ health service time investment

Accredited pharmacists invest significant time in performing comprehensive HMRs, especially during in-home patient consultations and during HMR report collation and completion. For a typical HMR, most spent: <30 minutes preparation, and 30-60 minutes in the home, and 1-3 hours in HMR report collation and completion. This significant HMR time investment as medicines experts provides insight for program and workforce considerations.

Pharmacy Practice 2021;19(3):2376.

Non-vitamin K antagonist oral anticoagulants, proton pump inhibitors and gastrointestinal bleeds

Concomitant treatment with a PPI in NOAC-treated patients with AF is associated with a reduced risk of severe upper GI bleeding. This indicates that PPI cotreatment can be considered, in particular among older patients, patients with a HAS-BLED score ≥3, and/or in patients on concomitant antiplatelet therapy.

Heart 2021

Can simvastatin reduce COPD exacerbations?

In a single-centre RCT including 209 patients with moderate to severe COPD, simvastatin at a dose of 40 mg daily significantly prolonged time to first COPD exacerbation and reduced exacerbation rate. Rate of exacerbations over 12 month period was 41% with simvastatin and 59% with placebo; and the annualised exacerbation rate was reduced by 23%.

European Respiratory Journal 2021;58:2001798.


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