Research Roundup

Debbie Rigby takes a look at the latest in research news

Probiotics for preventing gestational diabetes

A Cochrane review suggests there is an 85% increased relative risk of pre‐eclampsia with probiotic administration compared to placebo. Probiotics also may increase the risk of hypertensive disorders of pregnancy. Given the risk of harm and little observed benefit the authors caution in using probiotics during pregnancy.

Cochrane Database of Systematic Reviews 2021, Issue 4.

Electronic cigarettes for smoking cessation

A Cochrane Review has concluded that electronic cigarettes with nicotine increase quit rates compared to electronic cigarettes without nicotine and compared to nicotine replacement therapy. The unwanted effects reported most often with nicotine e‐cigarettes were throat or mouth irritation, headache, cough and feeling sick. These effects reduced over time as people continued using nicotine e‐cigarettes.

Cochrane Database of Systematic Reviews 2021, Issue 4.

Cardiovascular, mortality, and kidney outcomes with GLP-1 receptor agonists in patients with type 2 diabetes

A systematic review and meta-analysis of 8 randomised trials comprising 60 080 patients has concluded that GLP-1 receptor agonists reduce the risk of major adverse cardiac events, all-cause mortality, hospital admission for heart failure, and worsening kidney function in patients with type 2 diabetes.

Lancet Diabetes & Endocrinology, 2021.

Irritable bowel syndrome: an update on diagnosis and management

Irritable bowel syndrome (IBS) is a common chronic relapsing disorder, treating with a multimodal approach. Lifestyle and dietary modifications form the first-line treatment for IBS. For global IBS symptoms of abdominal pain and bloating probiotics, peppermint oil, Iberogast, tricyclic antidepressants and antispasmodics are recommended.

MedicineToday 2021;22(8):21-25.

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