Research Roundup

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Debbie Rigby rounds up the latest in research news

Placebos in clinical care: a suggestion beyond the evidence

Placebos provide important treatment effects but are often driven by myths and misunderstandings. Reviews that appropriately estimate the placebo effect as the difference in outcomes between placebo and no treatment groups suggest that placebos usually have modest effects. The authors suggest that it may be better to dismiss placebos and instead manage patients with evidence‐based treatments.

Med J Aust 2021; 215 (6): 252-253.e1.


Australian and New Zealand approach to diagnosis and management of vaccine‐induced immune thrombosis and thrombocytopenia

Vaccine‐induced immune thrombotic thrombocytopenia (VITT) or thrombosis with thrombocytopenia syndrome (TTS) is a potential complication of ChAdOx1‐nCov‐19 (AstraZeneca) vaccination. Diagnostic algorithms and treatment strategies for VITT are available and continue to be refined as local experience increases.

Med J Aust 2021; 215 (6): 245-249.e1.



B vitamins as a treatment for diabetic pain and neuropathy

A review of published literature has supported the use of B vitamins for diabetic neuropathy; although its overall efficacy remains uncertain and requires further study. The authors suggest a role for B vitamin combination therapy as a viable conservative primary or adjunctive therapy for patients with neuropathic pain. The evidence for analgesic and neuroprotective benefits of B vitamin therapy in diabetic patients remains limited.

J Clin Pharm Ther 2021;46(5):1199-1212.


Curcumin and rheumatoid arthritis

A systematic review of literature has concluded that curcumin is a useful anti-inflammatory in rheumatoid arthritis. The results of the only human study showed that curcumin significantly improved morning stiffness, walking time and joint swelling. No major adverse effects were reported in people who received up to 8g of curcumin per day for 3 months.

Int J Clin Pract 2021;75(10):e14280.

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