Debbie Rigby takes a look at the latest in research news
The TECOS study (Trial Evaluating Cardiovascular Outcomes with Sitagliptin) investigated the cardiovascular safety study of sitagliptin. All suspected cases of acute pancreatitis and pancreatic cancer were analysed, showing no statistically significantly difference between the sitagliptin and placebo groups. Meta-analysis suggests a small absolute increased risk for pancreatitis with DPP-4i therapy.
Diabetes Care 2016 Aug; dc152780.
A randomised controlled trial of 1,302 children with asthma aged 5 years and older taking probiotics or placebo has shown no difference in antibiotic prescribing for winter respiratory tract infections. There no evidence of an effect on respiratory tract infections or asthma exacerbations. Daily probiotic capsules contained 2 strains of Lactobacillus acidophilus, Bifidobacterium bifidum and B animalis (var lactis) at a total 2.5 × 1010 colony-forming units per capsule. The authors concluded that probiotics may not be effective for prophylaxis against URTIs.
Ann Fam Med 2016;14:422-430.
The American Headache Society Evidence-Based Guidelines recommended sumatriptan subcutaneous, zolmitriptan nasal spray, and high flow oxygen as first-line treatment for acute attacks. Verapamil is generally regarded as the maintenance prophylactic therapy of choice for cluster headaches.
Analysis of the Canadian pharmacist-led medication review service, Medscheck, has shown little or no effect on prescription drug use, deprescribing, patient loyalty, reduced drug costs, or improved adherence. The authors concluded that the program should be modified to be better targeted and encourage closer collaboration between pharmacists and prescribers.
Journal of the American Pharmacists Association 2016;56(5):513–520.