Research roundup

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Debbie Rigby takes a look at the latest in research news

Association of SGLT-2 Inhibitors and Diabetic Ketoacidosis

A US position statement on the prevalence of SGLT-2–associated DKA suggests that DKA occurs infrequently and that the risk-benefit ratio overwhelmingly favors continued use of SGLT-2 inhibitors with no changes in current recommendations. However the authors highlight that DKA diagnosis may be missed or delayed due to atypical presentation involving lower-than-anticipated glucose levels or other misleading laboratory values.

Endocr Pract. 2016;22(6):753-762. 


Incretin based drugs and the risk of pancreatic cancer

In this large, population based study the use of incretin based drugs was not associated with an increased risk of pancreatic cancer compared with sulfonylureas. During 2 024 441 person years of follow-up (median follow-up ranging from 1.3 to 2.8 years; maximum 8 years), 1221 patients were newly diagnosed as having pancreatic cancer (incidence rate 0.60 per 1000 person years). Compared with sulfonylureas, incretin based drugs were not associated with an increased risk of pancreatic cancer (pooled adjusted hazard ratio 1.02, 95% confidence interval 0.84 to 1.23).

BMJ 2016;352:i581


The role of the pharmacy in the management of bronchial asthma

A literature review of 7 observational studies and 14 interventional trials has shown active involvement of pharmacists in interventional trials consistently leads to an improvement of the quality of life, a better inhalation technique, and a reduction of exacerbations in patients with asthma. The authors suggest more specific training for pharmacists. Most of the studies were performed in Europe and Australia.

Annals of Allergy, Asthma & Immunology 2016 November 22


Efficacy of Turmeric Extracts and Curcumin for Alleviating the Symptoms of Joint Arthritis

A systematic review and meta-analysis of randomized clinical trials provided scientific evidence that 8–12 weeks of standardized turmeric extracts (typically 1000 mg/day of curcumin) treatment can reduce arthritis symptoms (mainly pain and inflammation-related symptoms) and result in similar improvements of the symptoms as ibuprofen and diclofenac sodium. The authors concluded that, although the studies used in this meta-analysis do not have sufficient number of subjects to permit a definitive recommendation for the use of curcumin as a treatment for arthritis, they do provide a compelling justification for its use as a dietary adjunct to conventional therapy.

J Med Food 2016;19(8):717–729.


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