Research roundup

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Debbie Rigby rounds up the latest in research news

Faecal Microbiota Transplantation in Clostridium difficile Infection: Evidence and Indications

Faecal microbiota transplantation aims to rapidly restore the normal diverse colonic microbiota by delivering a large inoculum of typical gut organisms in persons with symptomatic Clostridium difficile infection. FMT appears to be safe, with mild, self-limited adverse effects such as diarrhoea, cramping, belching, nausea, abdominal pain, fever, and dizziness.

American Family Physician 2017;95(6):351-2.


New-Onset Diabetes After Statin Exposure in Elderly Women

Data from the Australian Longitudinal Study on Women’s Health reveals high dose statin exposure is associated with a 33% higher risk of treatment for new-onset diabetes. The authors conclude older women currently taking statins should be carefully and regularly monitored for increased blood glucose to ensure early detection and appropriate management of this potential adverse effect, including consideration of de-prescribing.

Drugs & Aging. 2017;34(3):203–209.



Non-steroidal anti-inflammatory drug use is associated with increased risk of out-of-hospital cardiac arrest

Analysis of data from the nationwide Danish Cardiac Arrest Registry shows use of diclofenac (OR 1.50) and ibuprofen (OR 1.31) is associated with a significantly increased risk of out-of-hospital cardiac arrest. Use of naproxen, celecoxib and rofecoxib was not significantly associated with increased risk of cardiac arrest.

European Heart Journal – Cardiovascular Pharmacotherapy 2017;3:100–107.


Direct Oral Anticoagulants for the Prevention of Stroke in Nonvalvular Atrial Fibrillation

This review article summarises the benefits and potential adverse drug reactions and interactions of DOACs (dabigatran, apixaban, and rivaroxaban) in the management of NVAF. The advantages of DOACs over anticoagulation with warfarin include fixed dosing and no need for INR monitoring, although renal function should be checked periodically.

US Pharm. 2017;42(2):32-35.








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