Research Roundup

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Debbie Rigby takes a look at new research pertinent to pharmacy 

Efficacy of Tramadol Extended-Release for Opioid Withdrawal

The results of this trial suggest that tramadol ER is more effective than clonidine and comparable to buprenorphine in reducing opioid withdrawal symptoms during a residential 7-day tapering program. Tramadol ER was associated with less severe withdrawal symptoms relative to buprenorphine in the post-taper period. The doses of tramadol ER were up to 600 mg/day.

JAMA Psychiatry. Published online July 12, 2017.


Position statement on menopause–2017 update

The recently published American Association of Clinical Endocrinologists (AACE)/American College of Endocrinology (ACE) Position Statement is designed to update the previous menopause clinical practice guidelines published in 2011. New recommendations include use of menopausal hormone therapy in symptomatic postmenopausal women based on consideration of all risk factors for cardiovascular disease, age, and time from menopause and transdermal as compared with oral estrogen preparations may be considered less likely to produce thrombotic risk and perhaps the risk of stroke and coronary artery disease.

Endocrine Practice 2017;23(7):869-80.


The antibiotic course has had its day

The idea that stopping antibiotic treatment early encourages antibiotic resistance is not supported by evidence, while taking antibiotics for longer than necessary increases the risk of resistance. Patients are put at unnecessary risk from antibiotic resistance when treatment is given for longer than necessary, not when it is stopped early. For common bacterial infections no evidence exists that stopping antibiotic treatment early increases a patient’s risk of resistant infection. Antibiotics are a precious and finite natural resource which should be conserved by tailoring treatment duration for individual patients.

BMJ 2017;358:j3418

Medscape comment


Vitamin D Deficiency in Patients With Chronic Tension-Type Headache

This case-control study was carried out to examine the association between chronic tension-type headache and serum 25-hydroxy vitamin (25(OH) D) levels. One hundred consecutive adult (>18 years) patients with chronic tension-type headache and 100 matched healthy controls were enrolled. The results showed decreased serum 25(OHD) concentration was associated with chronic tension-type headache.

Headache 2017;57(7):1096–1108.
Medscape summary



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