Research Roundup

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Debbie Rigby takes a look at the latest in research news 

The evolving role of tiotropium in asthma

Tiotropium is a long-acting muscarinic antagonist (LAMA) now shown to improve lung function and control in asthma. This review discusses the evolving role of tiotropium delivered by the Respimat® in patients across the range of asthma severities and ages, and provides an overview of safety and efficacy data.

Journal of Asthma and Allergy 2017:10 231–236.


Probiotics for Gastrointestinal Conditions: A Summary of the Evidence

This article highlights the high-quality evidence that probiotics are effective for gastrointestinal conditions including acute infectious diarrhea, antibiotic-associated diarrhea, Clostridium difficile–associated diarrhea, hepatic encephalopathy, ulcerative colitis, irritable bowel syndrome, functional gastrointestinal disorders, and necrotizing enterocolitis. Conversely, there is evidence that probiotics are not effective for acute pancreatitis and Crohn disease.

Am Fam Physician. 2017;96(3):170-178.


Association of JNC-8 and SPRINT Systolic Blood Pressure Levels With Cognitive Function and Related Racial Disparity

Systolic blood pressure levels of 120 mm Hg or lower in older adults receiving treatment for hypertension is advantageous for cognition, especially for black individuals. This conclusion comes from the 10-year study called Healthy Aging and Body Composition study on 1657 older adults receiving treatment for hypertension.

JAMA Neurol. Published online August 21, 2017.

Medscape summary Editorial


The interfaces between vitamin D, sleep and pain

Poor sleep efficiency and sleep disorders have been shown to have an important role in hyperalgesia, and be associated with different vitamin D values. Vitamin D has been inversely correlated with painful manifestations, such as fibromyalgia and rheumatic diseases. The supplementation of vitamin D associated with good sleep hygiene may have a therapeutic role, not only in sleep disorders but also in the prevention and treatment of chronic pain conditions.

J Endocrinol 2017;234:R23-R36.


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