Research Roundup

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Debbie Rigby takes a look at the latest in research news 

We have had a gutful: The need for deprescribing proton pump inhibitors

Times series analysis of PBS and RPBS data shows a gradual increase between 2002 and 2010 and then gradual decrease of proton pump inhibitors. The authors suggest ongoing education and awareness campaigns for health professionals and patients, including electronic reminders at the point of prescribing, are strategies that have potential to reduce PPI use in individuals who do not have an evidence-based clinical indication for their long-term use.

Journal of Clinical Pharmacy and Therapeutics, online early 2017.


Lack of asthma and rhinitis control in general practitioner-managed patients prescribed fixed-dose combination therapy in Australia

This Australian study demonstrated a need for continuous education of patients with asthma as well as education of healthcare practitioners to better understand patient’s perceptions impact on asthma management. Only 11.5% of patients considered their asthma well controlled. Asthma medication use and inhaler technique were sub-optimal.

Journal of Asthma 2017


Clinical risks of St John’s Wort (Hypericum perforatum) co-administration

St. John’s wort (SJW) is a common medicinal herb used for the treatment of mild to moderate depression. SJW preparations have demonstrated clinically important interactions with several classes of conventional drugs such as immunosuppressants, anticancer agents, cardiovascular drugs, oral contraceptives, and lipid lowering agents that caused life-threatening events in several cases. Hyperforin seems to be the major ingredient responsible for CYP and P-gp inducing activity of SJW.

Expert Opinion on Drug Metabolism & Toxicology 2017.


Antibiotic therapy for children with acute otitis media

Acute otitis media is one of the most common infections in childhood. Signs and symptoms of acute otitis media include otalgia as well as tugging, rubbing, or holding of the ear. Routine prescription of antibiotics has led to adverse events and bacterial resistance to antibiotics. Treatment of acute otitis media includes administration of antipyretics and analgesics. Antibiotics should be promptly provided if the child’s infection worsens or fails to improve within 24 to 48 hours.

Canadian Family Physician 2017;63(9):685-687.


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