Research Roundup

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Debbie Rigby takes a look at the latest in research news 

Deprescribing antihyperglycemic agents in older persons

This guideline provides practical recommendations for making decisions about deprescribing antihyperglycemic agents. Deprescribing can include stopping the medication, dose reduction, or prescription substitution. Deprescribing antihyperglycemic agents is recommended when agents are causing hypoglycaemia and other adverse effects. Treatment targets need to be individualised and medications deprescribed accordingly for those who are frail, have dementia, or have a limited life expectancy.

Int J Clin Pract 2017;71:e13027.


Intra-Articular Corticosteroid Injections in Patients with Symptomatic Knee Osteoarthritis

In this prospective cohort study of 100 participants with knee osteoarthritis intra-articular corticosteroid injections improved pain and function at various time points (3 weeks, 6 weeks, 3 months and 6 months). The authors conclude that intra-articular corticosteroid injections may be an acceptable short-term management option in patients unwilling or unable to undergo surgical treatment. Obesity and OA severity affect the efficacy of intra-articular corticosteroid injections.

J Am Acad Orthop Surg. 2017;25(10):703-714. 


Functional dyspepsia

Functional dyspepsia refers to troublesome upper gastrointestinal symptoms including inability to finish a meal (early satiety), postprandial fullness, and epigastric pain or burning. Symptoms overlap with gastro-oesophageal reflux disease and irritable bowel syndrome. Treatment options include PPIs, H2-antagonists, low-dose TCAs and rifaximin; psychological therapy may be beneficial.

Aust Prescr 2017;40:209-13.


Unintentional mortality associated with paracetamol and codeine preparations, with and without doxylamine, in Australia

This study identified 441 deaths associated with codeine-combination analgesic products across three Australian states; with an average of 40 deaths per year. 102 cases involved the sedating antihistamine, doxylamine. Death commonly involved multiple substance use and abuse behaviours indicative of misuse and dependence.

Forensic Science International 2018;282:122-6.



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