Research Roundup

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Debbie Rigby rounds up the latest in research news

The role of the gut microbiome in systemic inflammatory disease

The role of the gut microbiome in models of inflammatory and autoimmune disease is now well characterized. This review summarizes the preclinical and clinical evidence on how dietary, probiotic, prebiotic, and microbiome based therapeutics affect our understanding of wellness and disease, particularly in autoimmunity.

BMJ 2018;360:j5145.


Pharmacologic Treatment of Hypertension in Adults Aged 60 Years or Older

The American College of Physicians (ACP) and the American Academy of Family Physicians (AAFP) jointly developed this guideline to present the evidence and provide clinical recommendations based on the benefits and harms of higher versus lower blood pressure targets for the treatment of hypertension in adults aged 60 years or older.

Ann Intern Med. 2017;166(6):430-437.


Noninvasive Treatments for Acute, Subacute, and Chronic Low Back Pain

The American College of Physicians (ACP) developed this guideline to present the evidence and provide clinical recommendations on non-invasive treatment of low back pain. Most patients with acute or subacute low back pain improve over time regardless of treatment. For patients with chronic low back pain, initial treatment with non-pharmacological therapies is recommended. In patients unresponsive, NSAIDs are recommended as second-line therapy.

Ann Intern Med. 2017;166(7):514-530.


The impact of non-vitamin K antagonist oral anticoagulants (NOACs) on anticoagulation therapy in rural Australia

A retrospective cohort study of patients hospitalised with a principal diagnosis of atrial fibrillation/flutter (AF) or venous thromboembolism (VTE) during 2014–2015 shows one-third of patients with AF and at risk of stroke received no anticoagulant therapy, and may benefit from NOAC therapy. In rural WA, about one-third of patients with an indication for anticoagulation therapy receive NOACs.

Med J Aust 2018; 208 (1): 18-23.


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