Research Roundup

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Debbie Rigby takes a look at the latest in research news

Treatment of vaginal atrophy with estriol and lactobacilli combination

The combination of a vaginal ultra-low dose of 0.03 mg of estriol (E3) and lyophilized, viable Lactobacillus acidophilus KS400 (0.03 mg-E3/L) could be considered one of the options for the treatment of symptomatic vaginal atrophy in menopausal women. The combination therapy is well tolerated with a low overall incidence of side-effects and negligible estriol absorption.

Climacteric, Published online: 30 Jan 2018.


Associations of Omega-3 Fatty Acid Supplement Use With Cardiovascular Disease Risks

A meta-analysis of 10 trials involving 77,917 individuals demonstrated that omega-3 fatty acids (EPA dose range 226-1800mg/day) had no significant association with fatal or nonfatal coronary heart disease or any major vascular events such as stroke. The mean duration of supplementation was 4.4 years. It provides no support for current recommendations for the use of such supplements in people with a history of coronary heart disease. The authors suggested that the results of the ongoing trials are needed to assess if higher doses of omega-3 FAs (3-4 g/d) may have significant effects on risk of major vascular events.

JAMA Cardiol. Published online January 31, 2018.

Medscape summary


Primary care models for treating opioid use disorders

Primary care-based models for Medication-Assisted Treatment (MAT) have been shown to reduce mortality for Opioid Use Disorder (OUD) and have equivalent efficacy to MAT in specialty substance treatment facilities. This systematic review concluded multidisciplinary and coordinated care delivery models are an effective strategy to implement OUD treatment and increase MAT access in primary care.

PLOS ONE 2017:1-40.


Vitamin D status in irritable bowel syndrome and the impact of supplementation on symptoms

Low vitamin D status is associated with risk of colorectal cancer and has been implicated in inflammatory bowel disease. Irritable bowel syndrome (IBS) is a chronic, relapsing, functional bowel disorder. This review of 4 observational studies and 3 RCTS suggests that low vitamin D status is common among the IBS population and merits assessment and rectification for general health reasons alone. An inverse correlation between serum vitamin D and IBS symptom severity is suggested and vitamin D interventions may benefit symptoms.

European Journal of Clinical Nutrition (2018).


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