Research Roundup

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Debbie Rigby rounds up the latest in research news

Fall-Risk-Increasing Drugs

Use of certain medications is recognized as a major and modifiable risk factor for falls. In this systematic review and meta-analysis of 131 studies, loop diuretics were significantly associated with increased fall risk, whereas beta-blockers were significantly associated with decreased fall risk. Digitalis and digoxin may increase the risk of falling, and statins may reduce it.

Journal of the American Medical Directors Association, 2018.


Trimethoprim use for urinary tract infection and risk of adverse outcomes in older patients

Among a cohort of 1 191 905 patients aged 65 and over, trimethoprim was associated with a greater risk of acute kidney injury and hyperkalaemia compared with other antibiotics used to treat UTIs, but not a greater risk of death. The relative risk increase is similar across population groups, but the higher baseline risk among those taking renin-angiotensin system blockers and potassium-sparing diuretics translates into higher absolute risks of acute kidney injury and hyperkalaemia in these groups.

BMJ 2018; 360


Effects of Lactobacillus rhamnosus and Lactobacillus acidophilus on bacterial vaginal pathogens

An in vitro study of two commercially existing probiotic strains, L. rhamnosus HN001 and L. acidophilus GLA-14 suggests that the combination inhibits the growth of a range of micro-organisms responsible for urogenital infections, such as bacterial vaginosis and aerobic vaginitis.

International Journal of Immunopathology and Pharmacology 2017;30(2):163–167.


Coprescribing proton-pump inhibitors with nonsteroidal anti-inflammatory drugs: risks versus benefits

This review discusses the GI effects and complications of NSAIDs and how PPIs may potentiate these effects, options for prevention of GI side effects, and appropriate use of PPIs in combination with NSAIDs.

Journal of Pain Research 2018;11:361–374.

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