Research Roundup

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Debbie Rigby takes a look at the latest in research news

Diagnosis and management of Parkinson’s disease in adults

In July 2017, NICE updated its 2006 guideline on Parkinson’s disease in adults, with major revisions to its recommendations on pharmacological and non-pharmacological management of motor and non-motor symptoms. This article provides a summary of the new guidance.

Prescriber. February 2018:25-8.

NICE guideline


Proton Pump Inhibitor Use and Dementia Risk

This large prospective population-based cohort study of people aged 65 years and older shows that proton pump inhibitor use is not associated with dementia risk, even for people with high cumulative exposure. Duration of PPI use was not associated with dementia outcomes either. The authors conclude that although there are other safety concerns with long-term PPI use, results from this study do not support that these medications should be avoided out of concern about dementia risk.

Journal of American Geriatrics Society 2018;66(2):247-253.


Chronic Cough: Evaluation and Management

Chronic cough in adults (cough lasting longer than eight weeks) is usually due to upper airway cough syndrome, gastroesophageal reflux disease/laryngopharyngeal reflux disease, asthma, or non-asthmatic eosinophilic bronchitis. In addition, ACE inhibitor–related cough has been reported in 5% to 35% of patients. Patients with refractory chronic cough may warrant may benefit from a trial of gabapentin, pregabalin, and/or speech therapy

Am Fam Physician. 2017;96(9):575-580.


Drug-Induced Restless Legs Syndrome

Several drugs and drug classes have been implicated in drug-induced restless legs syndrome (RLS), with antidepressants, antipsychotics, and antiepileptics having the most evidence. In addition, RLS may be linked with a number of disorders or underlying predisposing factors as well. Nonpharmacological management of RLS consists of the avoidance of caffeine, alcohol, and nicotine. Other suggestions include exercise, electrical stimulation, pneumatic compression, massage, and good sleep hygiene. Dopaminergic agents are used for treatment.

Annals of Pharmacotherapy, 2018;1-11.


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