Research Roundup

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Debbie Rigby takes a look at the latest in research news

Antidepressants plus benzodiazepines for adults with major depression

A Cochrane review has concluded combined antidepressant plus benzodiazepine therapy is more effective than antidepressants alone in improving depression severity, response in depression and remission in depression in the early phase (4 weeks). However, these effects are not maintained in the acute (5-12 weeks) or the continuous phase (more than 12 weeks).

Cochrane Database of Systematic Reviews 2019, Issue 6.


Anticholinergic medicines use among older adults before and after initiating dementia medicines

A study using PBS dispensing claims has shown use of anticholinergic medicines is common among patients initiating dementia medicines. The authors recommend periodic monitoring such as medicine reviews at the time of dementia diagnosis and thereafter to help prescribers identify and reduce potentially inappropriate medicine use and its detrimental effects.

Br J Clin Pharmacol. 2019;1–7.


Traveler’s diarrhea

Traveler’s diarrhea (TD) is defined as the sudden onset of loose or liquid stools while traveling. Symptoms can last for 2 to 4 days and include cramping, stomach pain, urgent stools, fever, vomiting, and bloody diarrhea. This 2-page infogrpahic details prevention before and during travel, and treatment during the trip. Azithromycin the preferred option for treatment for both moderate and severe TD.

Canadian Family Physician 2019;65(7):483-486.



Status of and strategies for improving adherence to COPD treatment

Inhaled drugs carry different implications for the evaluation of adherence than do oral medications. The Test of the adherence to inhalers (TAI) questionnaire is designed to assess adherence to inhaled medication. There are a few specific variables associated with treatment adherence in COPD including satisfaction with the inhaler, type of inhaler device, number of inhalers, dose regimen, specific comorbidities and health literacy.

International Journal of Chronic Obstructive Pulmonary Disease 2019;14:1503–1515.

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