Research Roundup


Debbie Rigby presents the latest research news relevant to pharmacy

Vitamin D and Lung Function Decline in Adults With Asthma

In this study of 395 adults with asthma, low serum 25(OH)D levels were weakly associated with more lung function decline in adults with asthma, and stronger associations were observed in never smokers and non-ICS users. Participants with low 25(OH)D (<50 nmol/L) had more decline in lung function measurements for forced expiratory volume in 1 second (FEV1), forced vital capacity, and the FEV1/forced vital capacity ratio over the follow-up, compared with those with high 25(OH)D (≥50 nmol/L).

Am J Epidemiol. 2016;183(8):739-746. 

 

Faecal Microbiota Transplantation

Faecal microbiota transplantation (FMT) has reported cure rates as high as 90% in clinical trials in the treatment of recurrent Clostridium difficile infection. The use of FMT in inflammatory bowel disease, functional gastrointestinal disorders, obesity and metabolic syndrome is still controversial.

BMJ Open Gastro. 2016;3(e000087) 

 

Adherence to Maintenance Medications among Older Adults with Chronic Obstructive Pulmonary Disease: The Role of Depression

New episodes of depression decrease adherence to maintenance medications used to manage COPD among older adults. Clinicians who treat older adults with COPD should be aware of the development of depression, especially during the first six months following COPD diagnosis, and monitor patients’ adherence to prescribed COPD medications to ensure best clinical outcomes.

Ann Am Thorac Soc. Published online June 22, 2016.
Medscape summary

Empagliflozin and Progression of Kidney Disease in Type 2 Diabetes

In patients with type 2 diabetes at high cardiovascular risk, empagliflozin was associated with slower progression of kidney disease and lower rates of clinically relevant renal events than was placebo when added to standard care.

New Engl J Med 2016. Published online June 14, 2016

 

 

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