Research Roundup

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Debbie Rigby takes a look at the latest in research news 

Risk Versus Benefit of Combined Aspirin and Warfarin Therapy in Patients With Atrial Fibrillation

In this retrospective, cohort study including patients from a pharmacist-run anticoagulation clinic, combination therapy with warfarin and aspirin increased bleeding risk compared to versus monotherapy with warfarin, with little benefit in decreasing AF-related stroke or cardiovascular events. Major bleeding occurred in patients on dual therapy at a 2-fold rate compared to warfarin alone. there was no difference in thromboembolic events.

Journal of Pharmacy Practice, first published April 15, 2020.


Benefits and Harms of Prescription Drugs and Supplements for Treatment of Clinical Alzheimer-Type Dementia

A systematic review and meta-analysis of 55 studies has shown that cholinesterase inhibitors and memantine slightly reduce short-term cognitive decline, and cholinesterase inhibitors slightly reduce reported functional decline, but differences versus placebo were of uncertain clinical importance. Evidence was mostly insufficient on drug treatment of BPSD and on supplements for all outcomes.

Ann Intern Med 2020.


What is the selection process for osteoarthritis pharmacotherapy?

This editorial provides a guide to the selection process of presently available pharmacotherapy in osteoarthritis. The basis of management should focus on self-management and education, lifestyle modifications, exercise and when appropriate, weight loss. Pharmacotherapy is targeted toward pain palliation with no agents available presently to target prevention and disease modification. The selection of pharmacotherapy should be tailored to the individual, taking into account of personal preferences and interactions with underlying co-morbidities.

Expert Opinion on Pharmacotherapy 2020


Vitamin D deficiency is associated with respiratory symptoms and airway wall thickening in smokers with and without COPD

Vitamin D deficiency was associated with increased respiratory symptoms, decreased functional status, increased frequency of severe exacerbations, as well as airway wall thickening on chest CT scans in this prospective cohort study with current and former smokers between ages 45 and 80 years.

BMC Pulmonary Medicine 2020;20:123.


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1 Comment

  1. Warfarin + Aspirin? I thought warfarin is obsolete. Surely apixaban etc are now the only therapy.

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