Research Roundup


Treatment of vulvovaginitis

Vulvovaginitis usually presents with irritation and vaginal discharge. Bacterial vaginosis typically presents with malodorous (often fishy) vaginal discharge. Antifungals and antibiotics are used in management of vulvovaginitis. Treatment options for bacterial vaginosis include oral or intravaginal metronidazole or clindamycin.

Aust Prescr 2020;43:195-9.

Effect of Cannabidiol and Δ9-Tetrahydrocannabinol on Driving Performance

In this small crossover clinical trial that included 26 healthy participants who underwent on-road driving tests, there was no statistically significant differences in driving performance during experimental on-road driving tests between CBD-dominant cannabis and placebo. It is important to note that the doses tested may not represent common usage.

JAMA. 2020;324(21):2177-2186.

Editorial

Updated Australian guidelines for mild asthma: what’s changed and why?

The Australian asthma guidelines have recently been updated and include additional treatment options for adults and adolescents with mild asthma. For adults and adolescents with mild asthma, the updated guidelines include as-needed inhaled low-dose budesonide–formoterol as an alternative to daily low-dose inhaled corticosteroid plus as-needed short-acting beta2 agonist.

Aust Prescr 2020;43:220-4.

Effect of vitamin D supplementation on asthma control in patients with vitamin D deficiency

In this randomised triple-blind, placebo-controlled trial on 112 patients with serum 25-hydroxyvitamin-D3 <30 ng/mL, supplementation with weekly oral calcifediol (25- hydroxyvitamin D3) compared with placebo improved asthma control over 6 months. The intervention group received oral supplementation with 16 000 IU of calcifediol per week. To achieve clinically significant improvement in the Asthma Control Test, the NNT with vitamin D supplements was 3.73 patients.

Thorax 2020.

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