Research Roundup

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Debbie Rigby takes a look at the latest in research news

Improving the Management of COPD in Women

Chronic obstructive pulmonary disease (COPD) is a highly debilitating disease that represents a substantial and growing health burden in women. There is increasing evidence for gender-related differences in COPD risk, progression and outcomes. However, the disease receives scant attention as a women’s health issue. This review article highlights suggestions for achieving better outcomes for women.

Chest, Available online 2 November 2016


Effect of Cranberry Capsules on Bacteriuria Plus Pyuria Among Older Women in Nursing Homes

Cranberry has been recommended to prevent recurrent urinary tract infections. However a randomised control trial of 185 older people (mean age 86.4 years) has shown cranberry capsules have no significant difference in presence of bacteriuria plus pyuria over 1 year compared to placebo. Two oral cranberry capsules, each capsule containing 36mg of the active ingredient proanthocyanidin (20 ounces of cranberry juice) administered once a day.

JAMA. 2016;316(18):1879-1887.



Cardiovascular Safety of Celecoxib, Naproxen, or Ibuprofen for Arthritis

A randomised controlled trial of 24,081 patients has concluded that moderate doses of celecoxib (200mg daily) are non-inferior to ibuprofen or naproxen with regard to cardiovascular safety. The risk of gastrointestinal events was significantly lower with celecoxib than with naproxen or ibuprofen; and the risk of renal events was significantly lower with celecoxib than with ibuprofen but was not significantly lower with celecoxib than with naproxen.

New Engl J Med, November 13, 2016.

Perspective in Circulation


What to Believe and Do About Statin-Associated Adverse Effects

The effectiveness and safety of statins have been documented by numerous RCTs; however concerns about possible statin-associated adverse effects impact negatively on patient adherence. This article discusses the true incidence and management of statin-associated muscle symptoms.

JAMA 2016;316:1969-70.



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