Research Roundup

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Debbie Rigby takes a look at the latest in research news

Role of Direct Oral Anticoagulants in the Management of Anticoagulation

This article reviews the roles of dabigatran, rivaroxaban, apixaban, and edoxaban in stroke prevention in nonvalvular atrial fibrillation, for prevention of venous thromboembolism after orthopedic surgery, and in the treatment of venous thromboembolism. Direct oral anticoagulants are at least as efficacious and safe as traditional anticoagulation therapy.

South Med J. 2017;110(4):293-299.


Proton Pump Inhibitors and Risk of Mild Cognitive Impairment and Dementia

An observational study has shown no link between use of proton pump inhibitors and greater risk of dementia or Alzheimer’s disease. Continuous and intermittent use was associated with lower risk of decline in cognitive function and lower risk of conversion to mild cognitive impairment (MCI) or Alzheimer’s disease compared to never use. This lower risk was found for persons with normal cognition or MCI.

J Am  Geriatr Soc 2017.


Topical analgesics for acute and chronic pain in adults

An overview of 13 individual Cochrane reviews (206 studies with around 30,700 participants) has concluded that topical therapy with diclofenac Emugel is effective for acute musculoskeletal pain conditions (strains and sprains). In chronic pain musculoskeletal conditions (mainly hand and knee osteoarthritis) topical diclofenac preparations over < 6 weeks is effective. In postherpetic neuralgia topical high-concentration capsaicin had moderate-quality evidence of limited efficacy.

Cochrane Database of Systematic Reviews 2017, Issue 5. Art. No.: CD008609.


Aspirin versus Placebo in Pregnancies at High Risk for Preterm Preeclampsia

Use of low-dose aspirin in women at high risk for preterm preeclampsia results in a lower incidence of this diagnosis than placebo. In this multicenter, double-blind, placebo-controlled trial, over 1700 high-risk women with singleton pregnancies were randomized to receive 150-mg aspirin or placebo daily from 11–14 weeks’ gestation until 36 weeks. Preterm preeclampsia occurred in 13 participants (1.6%) in the aspirin group, as compared with 35 (4.3%) in the placebo group.

New Engl J Med, published on June 28, 2017.


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