Research Roundup

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Debbie Rigby rounds up the latest in research news

Diagnosis and management of allergic rhinitis in children

Allergic rhinitis is a very common disease of childhood that can have considerable impact on quality of life. This article discusses the diagnosis of allergic rhinitis in children and the management options that can be tried, including allergen avoidance, pharmacological therapies and allergen immunotherapy.

Prescriber, December 2017.


Type 2 diabetes mellitus and bone

Type 2 diabetes is associated with an increased risk of fracture, particularly of the hip, despite normal or high bone mineral density. Longer duration of disease and poor glycaemic control are both associated with higher fracture risk. Increased falls risk, obesity, sarcopenia and co-morbidities are likely to contribute to increased fracture risk.

Journal of Internal Medicine, accepted manuscript online: 19 December 2017.


Type 2 Diabetes and Osteoporosis: A Guide to Optimal Management

The aim of this article is to review updated information on osteoporosis and fracture risk in patients with T2D, to discuss the effects of diabetes treatment on bone metabolism, as well as the effect of antiosteoporotic medications on the incidence and control of T2D, and to provide a personalized guide to the optimal management. Metformin, sulfonylureas, dipeptidyl peptidase-4 inhibitors, and glucagon-like peptide-1 receptor agonists should be preferred for the treatment of T2D, whereas strict targets should be avoided for the fear of hypoglycemia, falls, and fractures.

J Clin Endocrinol Metab. 2017;102(10):3621-3634.


Incremental effects of antihypertensive drugs

Secondary data analysis of the SPRINT study, shows the addition of a new antihypertensive medication class leads to large reduction in systolic blood pressure and fewer major cardiovascular events. The addition of another antihypertensive drug class was not associated with adverse events. The SPRINT study compared intensive blood pressure treatment versus standard treatment (target < 140mmHg).

BMJ 2017;359:j5542.

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