Research Roundup

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Debbie Rigby examines the latest in research news

Dual antiplatelet therapy: how, how long, and in which patients?

Dual antiplatelet therapy is a crucial therapeutic intervention in patients with stable or acute coronary artery disease. However, the duration of dual antiplatelet therapy and its combination with anticoagulants in certain patients remain clinical challenges. The risk of bleeding associated with dual antiplatelet therapy prolongation beyond 1 year does not seem to be justified by the small absolute gain in preventing stent thrombosis.

European Heart Journal 2018;39(3):181-3.


New Therapies in Irritable Bowel Syndrome: What Works and When

Traditional treatments such as antispasmodics, antidepressants, dietary and lifestyle modifications are important in the treatment of IBS with the newer agents to be considered wherever these treatments are ineffective or poorly tolerated. Probiotics may normalize intestinal dysmotility, enhance intestinal barrier function, reduce circulating levels of pro-inflammatory cytokines and improve visceral hypersensitivity.

Curr Opin Gastroenterol. 2018;34(1):50-56.


Medications That Cause Dry Mouth As an Adverse Effect in Older People

Medication use is significantly associated with xerostomia and salivary gland hypofunction in older adults. The risk of dry mouth was greatest for drugs used for urinary incontinence (tolterodine, duloxetine, oxybutynin). Several psycholeptic medications, including particular antipsychotics, anxiolytics, and hypnotics, are also prone to causing dry mouth.

J Am Geriatr Soc 2018;66:76–84.


Postsurgical prescriptions for opioid naive patients and association with overdose and misuse

The retrospective study of over half a million patients receiving post-operative opioids shows each refill and week of opioid prescription is associated with a large increase in opioid misuse among opioid-naïve patients. Total duration of opioid use was the strongest predictor of misuse in the early post-surgical period.

BMJ 2018;360:j5790.




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