Research Roundup

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Debbie Rigby takes a look at the latest in research news

The associations between serum 25-hydroxyvitamin D level and the risk of total fracture and hip fracture

In this meta-analysis of 16 prospective cohort studies and three nested case–control studies, low serum 25(OH) vitamin D level was associated with increased risks of total (RR 1.25) and hip fractures (RR 1.48).

Osteoporosis International 2017;28(5):1641–1652.


Role of Long-Acting Muscarinic Antagonist/Long-Acting β2-Agonist Therapy in Chronic Obstructive Pulmonary Disease

This analysis of 10 randomised controlled trials reviewed the use of LAMA/LABA compared with ICS/LABA therapy for COPD maintenance therapy. LAMA/LABA combination therapy demonstrated significant improvements in pulmonary function tests compared to ICS/LABA, as well as improved clinical outcomes with LAMA/LABA therapy, specifically reduction in COPD exacerbation rates. The safety of LAMA/LABA combination therapy also is favorable compared with ICS/LABA combination therapy because of the increased infection risk with ICS therapy. 

Annals of Pharmacotherapy 2017;1–10.


Long-term persistence and adherence on urate-lowering treatment

Nurse-led treatment of gout improves persistence and adherence on urate-lowering treatment (ULT) in primary care. Initial treatment that includes individualized patient education and involvement in treatment decisions resulted in excellent adherence and persistence on ULT >4 years after the responsibility of treatment is taken over by the patient’s general practitioner.

Rheumatology (Oxford) (2017) 56 (4): 529-533.


The degree of integration of non-dispensing pharmacists in primary care practice and the impact on health outcomes

A non-dispensing pharmacist conducts clinical pharmacy services aimed at optimizing patients individual pharmacotherapy. Embedding a non-dispensing pharmacist in primary care practice enables collaboration enhances patient care. This literature review concludes that full integration adds value to patient-centered clinical pharmacy services.

Research in Social & Administrative Pharmacy (2017), doi: 10.1016/j.sapharm.2017.04.014.


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