Research Roundup

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Debbie Rigby takes a look at the latest in research news, focusing on COVID-19

A Rush to Judgment? Rapid Reporting and Dissemination of Results and Its Consequences Regarding the Use of Hydroxychloroquine for COVID-19

There currently are no data to recommend the use of HCQ as prophylaxis for COVID-19. The HCQ shortage not only will limit availability to patients with COVID-19 if efficacy is truly established but also represents a real risk to patients with rheumatiod arthritis and systemic lupus erythematosus who depend on HCQ for their survival.

Ann Intern Med. 2020.


Potential Effects of Coronaviruses on the Cardiovascular System

COVID-19 is associated with a high inflammatory burden that can induce vascular inflammation, myocarditis, and cardiac arrhythmias. A large proportion of affected patients to date have been reported to have underlying cardiovascular disease.

JAMA Cardiol. Published online March 27, 2020.


Cardiovascular disease and COVID-19: Australian/New Zealand consensus statement

Pre-existing cardiovascular disease (CVD) increases the morbidity and mortality of COVID-19, and COVID-19 itself causes serious cardiac sequelae. Common acute cardiac manifestations of COVID-19 include left ventricular dysfunction, heart failure, arrhythmias and acute coronary syndromes. Patients with pre-existing CVD are more susceptible to life-threatening SARS-CoV-2 infection.

Med J Aust, published online 3 April 2020.


COVID-19 rapid guideline: managing symptoms (including at the end of life) in the community

NICE guideline on managing symptoms provides advice to health professionals on the management of cough, fever, breathlessness and anxiety, delirium and agitation in those with COVID-19.  It includes approaches for managing these symptoms such as considering the use of paracetamol in people with fever. People are advised to first treat a mild cough with simple measures and should also avoid lying on their back as this can make coughing, which helps clear the lungs, more difficult.

NICE Guideline, published 3 April 2020.

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