Use of this commonly prescribed antidepressant has been linked with an increased risk of birth defects, according to a recent analysis
Fluoxetine is the most commonly prescribed antidepressant in the world.
In the analysis of 16 studies, infants exposed to fluoxetine during the first trimester had an 18% increased relative risk of major malformations and a 36% increased relative risk of cardiovascular malformations.
There were no significant observations of other system-specific malformations in the nervous system, eye, urogenital system, digestive system, respiratory system, or musculoskeletal system.
The findings are published in the British Journal of Clinical Pharmacology.
The researchers, from the Shengjing Hospital of China Medical University, Shenyang, China, searched the PubMed and Web of Science databases from inception to 21March 2016. Additional studies were identified in a manual search of the reference lists.