Research Roundup

Debbie Rigby rounds up the latest in research news

Melatonin for children with autism spectrum disorder

Behavioural therapy is the first-line treatment for sleep problems in children with autism spectrum disorder; however, melatonin has been reported to be effective and safe in this population as an alternative or adjunctive treatment. Prolonged-released formulation of melatonin is doses of 2, 5 or 10mg/day, has shown promise in initial clinical trials in shortening sleep latency and increasing total sleep time.

Canadian Family Physician 2020;66:183-5.


Acupuncture for low back pain

Acupuncture is an effective treatment for relief from low back pain, even when compared with other interventions (sham acupuncture, usual care, or no treatment), with stronger effects observed immediately after treatment. Clinically significant reduction in pain is more reliably observed in chronic rather than acute low back pain.

Canadian Family Physician March 2020;66(3):186-187.


Understanding Patient Perspectives on Medication Adherence in Asthma

Adherence to asthma medications is generally poor and undermines clinical outcomes. Patients’ perceived lack of need for asthma medications and medication concerns are key drivers of poor medication adherence. The perceived lack of impact of asthma on daily life may also contribute to patients’ uncertainty about the accuracy of their diagnosis and hence adherence to therapy.

Patient Preference and Adherence 2020;14:541–551.


Clinically relevant drug interactions between statins and antidepressants

Fluoxetine, paroxetine and fluvoxamine influence considerably CYPs activity with potential effects on statins plasma levels. Citalopram, escitalopram, mirtazapine, reboxetine and venlafaxine, have weak inhibitory effects on various cytochrome (CYP) isozyme and are less likely to cause clinically relevant pharmacokinetic drug interactions. Pharmacodynamic drug‐drug interactions are unlikely to occur as statins. No studies have been performed on P‐glycoprotein (P‐gp); however, interactions of clinical relevance are unlikely.

Journal of Clinical Pharmacy and Therapeutics 2020;45(2):227-39.

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