Research Roundup

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Debbie Rigby takes a look at the latest in research news 

Aging and extrapulmonary effects of chronic obstructive pulmonary disease

People with COPD experience a decline in functional status including reduced exercise capacity and muscle strength, deteriorated cognitive function and increased inflammatory markers. In this study of 62 patients with COPD, inflammation markers were significantly correlated with muscle strength, walking distance and cognitive impairment. Exercise is the only non-pharmacological intervention associated with antiaging effect.

Clinical Interventions in Aging 2017:12 1281–1287.


Long-term clinical and immunological effects of probiotic and peanut oral immunotherapy after treatment cessation

A follow-up study four years after treatment cessation of combined probiotic and peanut oral immunotherapy (PPOIT) shows long-lasting clinical benefit and persistent suppression of the allergic immune response to peanut. Of 56 children with peanut allergy who were randomized to receive either combined probiotic (Lactobacillus rhamnosus CGMCC 1.3724, 2 x 1010 CFU) and peanut oral immunotherapy or placebo daily for 18 months, 90% and 7% were desensitized to peanuts following treatment, respectively. At follow-up, children who had been randomized to combination therapy were significantly more likely than placebo recipients to continue eating peanuts (67% vs. 4%).

Lancet Child & Adolescent Health 2017

Initial study


Faecal microbiota transplantation for Clostridium difficile-associated diarrhoea

Faecal microbiota transplantation (FMT) has emerged as a useful approach for treating Clostridium difficile-associated diarrhoea (CDAD). A systematic review of randomised controlled trials has concluded that FMT is more effective in patients with CDAD than vancomycin or placebo.  Frozen FMT preparations are as efficacious as fresh material in one RCT.

Med J Aust 2017; 207 (4): 166-172.

Editorial Podcast


The Effects of Cannabis Among Adults With Chronic Pain and an Overview of General Harms

A systematic review of 27 chronic pain trials has concluded that there is low-strength evidence that cannabis alleviates neuropathic pain but insufficient evidence in other pain populations. According to 11 systematic reviews and 32 primary studies, harms in general population studies include increased risk for motor vehicle accidents, psychotic symptoms, and short-term cognitive impairment.

Ann Intern Med. 2017.


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