Research Roundup

SGLT2 inhibitors, NSAIDs, budesonide-formoterol reliever therapy and medication review in RACFs

SGLT2 inhibitors for the prevention of kidney failure in patients with type 2 diabetes

A systematic review of 4 studies provides substantiveevidence supporting the use of SGLT2 inhibitors to prevent major kidney outcomes in people with type 2 diabetes. SGLT2 inhibitors reduced the risk of dialysis, transplantation, or death due to kidney disease. SGLT2 inhibitors also reduced end-stage kidney disease by 35% and acute kidney injury by 25%.

Lancet Diabetes & Endocrinology, published 5 September 2019.


Role of Nonsteroidal Anti-inflammatory Drugs in the Association Between Osteoarthritis and Cardiovascular Diseases

This longitudinal study from Canada suggests that NSAID use contributes substantially to an increased risk of cardiovascular disease (CVD) among patients with osteoarthritis. Approximately 41% of the total effect of OA on increased CVD risk was mediated through NSAIDs.

Arthritis & Rheumatology, first published 6 August 2019.


Budesonide-formoterol reliever therapy versus maintenance budesonide plus terbutaline reliever therapy in adults with mild to moderate asthma (PRACTICAL)

Results from a 52-week open-label RCT show budesonide–formoterol used as needed for symptom relief is more effective at preventing severe exacerbations than maintenance low-dose budesonide plus as-needed terbutaline in adults with mild to moderate asthma.

Lancet, published 23 August 2019.



Process, impact and outcomes of medication review in Australian residential aged care facilities

A systematic review of stand‐alone medication review or reconciliation interventions in Australian RACFs identified an average of 2.7‐3.9 medication‐related problems (MRPs) per resident. Three studies reported general practitioners’ acceptance of pharmacists’ recommendations to resolve MRPs, ranging between 45 and 84%. This highlights the value of pharmacists and GPs working together to optimise medication management in this setting.

Australasian Journal on Ageing 2019;38 (suppl 2):9-25.

Previous Health ‘blitz’ on ORT
Next ‘My trust has been broken.’

NOTICE: It can sometimes take awhile for comment submissions to go through, please be patient.

No Comment

Leave a reply