Research Roundup

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Debbie Rigby rounds up the latest in research news

Interventions to improve adherence to inhaled steroids for asthma

A Cochrane review of 39 RCTs on adherence to inhaled corticosteroids in asthma shows adherence education, electronic trackers or reminders and simplified regimens are effective. Adherence education showed a benefit of 20 percentage points over usual asthma care; electronic trackers or reminders led to better adherence of 19 percentage points; and simplified regimens led to better adherence of four percentage points.

Cochrane Database of Systematic Reviews 2017, Issue 4.


Opioid analgesics-related pharmacokinetic drug interactions

This narrative review examines opioid analgesics-related pharmacokinetic drug-drug interactions. The authors concluded that effective and safe combination therapy of opioids can be achieved by promoting the awareness of potential changes in therapeutic efficacy and toxicities, prescribing alternatives or changing administration strategy, tailoring dose, reviewing the appropriateness of orders, and paying attention to medication monitoring.

Journal of Pain Research 2017:10 1225–1239.


10 years of denosumab treatment in postmenopausal women with osteoporosis

Results from the seven-year extension phase of the FREEDOM trial shows that 10 year treatment with denosumab is associated with low rates of adverse events, low fracture incidence compared with that observed during the original trial, and continued increases in BMD without plateau.

The Lancet Diabetes & Endocrinology 2017.


Withdrawal of antihypertensive medication

A systematic review of available evidence shows that around one-quarter of mainly older patients on antihypertensive therapy can withdraw such medication without return of hypertension for two or more years. Adverse events were more common in those who withdrew but were minor and included headache, joint pain, palpitations, oedema and a general feeling of being unwell.

Journal of Hypertension 2017;35:000–000.

Medscape summary


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