Cannabis-based medicines should be used carefully until more evidence is accumulated, a drug expert has cautioned
Professor Wayne Hall, from the University of Queensland’s Centre for Youth Substance Abuse Research, says that these medicines should only be used under medical supervision until more clinical studies have assessed their safety and efficacy.
He said a recent survey on cannabis use to treat anxiety, depression, pain and sleep difficulties highlighted the need for evidence-based research.
“While participants suggested that cannabis was effective in treating their primary problems, they also experienced side effects including drowsiness, lethargy, memory impairment and paranoia,” he said.
Prof Hall has written an editorial in the Medical Journal of Australia, The challenges in providing safe, effective, affordable cannabis-based medicines for unapproved indications, in which he writes that while the survey provides useful information about the use among Australians of illicit cannabis for medical purposes, it does not provide a representative sample of the general population.
“The 1748 participants completed an anonymous online survey to minimise concerns about disclosing illegal activity, and medical cannabis websites and Facebook groups were used for recruitment,” Prof Hall said.
“The sample didn’t include many patients with terminal cancer or older adults with degenerative neurological disorders, and children with epilepsy weren’t included at all.”
Instead, participants were predominantly men (68%), with an average age of 37.9 years, and a 10-year history of using cannabis for medical purposes.
Most had used cannabis for recreational reasons in their teens.
“The survey has given us some insight into who uses cannabis for medical purposes in Australia, why and how they use it, and their views on how cannabis should be provided for medical purposes,” Professor Hall said.
“We need to understand why people want to use cannabis to treat conditions such as anxiety and depression because there isn’t a lot of evidence on its short or long term effectiveness or safety in these conditions.
“Government policies funding clinical trials and allowing some people to access medicinal cannabis are sensible, and in the future should enable doctors to more effectively and safely use cannabis-based medicines to treat illnesses.”
In Queensland, medicinal cannabis can be approved for use for conditions in palliative care, epilepsy, chemotherapy-induced nausea and vomiting, multiple sclerosis and chronic pain.
A number of clinical trials are being conducted in Australia to establish an evidence base for medicinal cannabis use and inform future treatment decisions.
The survey, and commentary by Professor Hall, are published in the MJA.